72,528
XNAS Volume
High volume today
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Donini Oreola | CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 20,000 | 20,000 | - | - | Option (Right to Buy) | |
| Jonathan L. Guarino | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 20,000 | 20,000 | - | - | Option (Right to Buy) | |
| Diane Parks L. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 8,646 | 8,646 | - | - | Stock Option (Right to Buy) | |
| Richard Straube | SENIOR VICE PRESIDENT AND CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 12,000 | 12,000 | - | - | Option (Right to Buy) | |
| J. Robert Rubin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 8,646 | 8,646 | - | - | Stock Option (Right to Buy) | |
| Zeldis Bernard Jerome | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 8,646 | 8,646 | - | - | Stock Option (Right to Buy) | |
| Schaber Christopher J. | Director, CHAIRMAN, CEO AND PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 45,000 | 45,000 | - | - | Option (Right to Buy) | |
| Gregg Anthony Lapointe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 8,646 | 8,646 | - | - | Stock Option (Right to Buy) | |
| Parks L. Diane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2023 | 38,136 | 38,136 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2023 | 38,136 | 38,136 | - | - | Stock Option (Right to Buy) | |
| Anthony Lapointe Gregg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2023 | 38,136 | 38,136 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2023 | 38,136 | 38,136 | - | - | Stock Option (Right to Buy) | |
| Richard Straube | SENIOR VICE PRESIDENT AND CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 75,000 | 75,000 | - | - | Option (Right to Buy) | |
| Donini Oreola | CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 90,000 | 90,000 | - | - | Option (Right to Buy) | |
| Jonathan Guarino L. | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 90,000 | 90,000 | - | - | Option (Right to Buy) | |
| J. Schaber Christopher | Director, CHAIRMAN, CEO AND PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 150,000 | 150,000 | - | - | Option (Right to Buy) | |
| Timothy R. Cote | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2023 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Nov 2022 | 46,154 | 126,753 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Nov 2022 | 46,154 | 129,747 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Nov 2022 | 46,154 | 145,285 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Nov 2022 | 46,154 | 112,504 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, CHAIRMAN, CEO AND PRESIDENT | Purchase of securities on an exchange or from another person at price $ 0.44 per share. | 18 May 2022 | 20,000 | 90,095 (0%) | 0% | 0.4 | 8,866 | Common Stock |
| Richard Straube | SENIOR VICE PRESIDENT AND CMO | Purchase of securities on an exchange or from another person at price $ 0.50 per share. | 18 May 2022 | 8,000 | 8,000 (0%) | 0% | 0.5 | 4,000 | COMMON STOCK |
| Christopher J. Schaber | Director, CHAIRMAN, CEO AND PRESIDENT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, CHAIRMAN, CEO AND PRESIDENT | Purchase of securities on an exchange or from another person at price $ 0.74 per share. | 17 Dec 2021 | 7,000 | 70,095 (0%) | 0% | 0.7 | 5,179 | COMMON STOCK |
| Jonathan L. Guarino | Senior Vice President and CFO | Purchase of securities on an exchange or from another person at price $ 0.70 per share. | 15 Dec 2021 | 1,000 | 11,000 (0%) | 0% | 0.7 | 700 | COMMON STOCK |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.73 per share. | 14 Dec 2021 | 10,000 | 63,095 (0%) | 0% | 0.7 | 7,269 | COMMON STOCK |
| Jonathan L. Guarino | Senior Vice President and CFO | Purchase of securities on an exchange or from another person at price $ 0.71 per share. | 14 Dec 2021 | 10,000 | 10,000 (0%) | 0% | 0.7 | 7,119 | COMMON STOCK |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2021 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Richard Straube | CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2021 | 40,000 | 40,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2021 | 70,000 | 70,000 | - | - | Option (Right to Buy) | |
| Jonathan L. Guarino | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2021 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2021 | 29,126 | 29,126 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2021 | 29,126 | 29,126 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2021 | 29,126 | 29,126 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2021 | 29,126 | 29,126 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | Director | Sale of securities on an exchange or to another person at price $ 0.90 per share. | 14 May 2021 | 3,000 | 22,917 (0%) | 0% | 0.9 | 2,701 | Common Stock |
| Jerome Bernard Zeldis | Director | Purchase of securities on an exchange or from another person at price $ 0.89 per share. | 14 May 2021 | 3,000 | 25,917 (0%) | 0% | 0.9 | 2,664 | Common Stock |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2020 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Richard Straube | CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2020 | 40,000 | 40,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2020 | 70,000 | 70,000 | - | - | Option (Right to Buy) | |
| Jonathan L. Guarino | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2020 | 15,228 | 15,228 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2020 | 15,228 | 15,228 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2020 | 15,228 | 15,228 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2020 | 15,228 | 15,228 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 13,500 | 13,500 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2020 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Richard Straube | SVP and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 30,000 | 30,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | SVP and CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Jonathan L. Guarino | Senior Vice President & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.93 per share. | 19 Nov 2019 | 10,770 | 53,095 (0%) | 0% | 0.9 | 10,016 | Common Stock |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.92 per share. | 19 Nov 2019 | 2,000 | 22,917 (0%) | 0% | 0.9 | 1,850 | Common Stock |
| Diane L. Parks | None | Purchase of securities on an exchange or from another person at price $ 0.93 per share. | 23 Sep 2019 | 14,940 | 14,940 (0%) | 0% | 0.9 | 13,870 | Common Stock |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.94 per share. | 19 Sep 2019 | 4,000 | 20,917 (0%) | 0% | 0.9 | 3,740 | Common Stock |
| Jonathan L. Guarino | Senior Vice President and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2019 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2019 | 30,928 | 30,928 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2019 | 30,928 | 30,928 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2019 | 30,928 | 30,928 | - | - | Stock Option (Right to Buy) | |
| Mark E. Pearson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2019 | 30,928 | 30,928 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2019 | 30,928 | 30,928 | - | - | Stock Option (Right to Buy) | |
| Diane L. Parks | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2019 | 1,500 | 1,500 | - | - | Stock Option (Right to Buy) | |
| Mark E. Pearson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.71 per share. | 28 Jun 2019 | 78,338 | 78,338 (0%) | 0% | 0.7 | 55,620 | Common Stock |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.72 per share. | 22 Apr 2019 | 5,000 | 42,325 (0%) | 0% | 0.7 | 3,577 | Common Stock |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.73 per share. | 22 Apr 2019 | 10,000 | 16,917 (0%) | 0% | 0.7 | 7,274 | Common Stock |
| Christopher J. Schaber | Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2019 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 60,000 | 60,000 | - | - | Option (Right to Buy) | |
| Karen Krumeich | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 40,000 | 40,000 | - | - | Option (Right to Buy) | |
| Richard Straube | SVP and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 40,000 | 40,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | SVP and CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 40,000 | 40,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 1.17 per share. | 18 Oct 2018 | 8,700 | 37,325 (0%) | 0% | 1.2 | 10,177 | Common Stock |
| Mark E. Pearson | None | Purchase of securities on an exchange or from another person at price $ 1.16 per share. | 17 Oct 2018 | 170,000 | 2,500,000 (14%) | 0% | 1.2 | 197,200 | Common Stock |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,964 | 17,964 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,964 | 17,964 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,964 | 17,964 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,964 | 17,964 | - | - | Stock Option (Right to Buy) | |
| Mark E. Pearson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,964 | 17,964 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 22 Aug 2018 | 3,530 | 28,625 (0%) | 0% | 1.4 | 5,012 | Common Stock |
| Mark E. Pearson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jul 2018 | 1,500 | 1,500 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2017 | 80,000 | 80,000 | - | - | Option (Right to Buy) | |
| Karen Krumeich | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2017 | 35,000 | 35,000 | - | - | Option (Right to Buy) | |
| Richard Straube | SVP and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2017 | 35,000 | 35,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | SVP and CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2017 | 35,000 | 35,000 | - | - | Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 13,100 | 13,100 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 13,100 | 13,100 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 13,100 | 13,100 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 13,100 | 13,100 | - | - | Stock Option (Right to Buy) | |
| Marco M Brughera | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 13,100 | 13,100 | - | - | Stock Option (Right to Buy) | |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.54 per share. | 04 May 2017 | 1,881 | 85,397 (1%) | 0% | 2.5 | 4,778 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | 04 May 2017 | 250,000 | 0 | - | - | Warrant to Purchase Common Stock | ||
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.70 per share. | 04 May 2017 | 71,607 | 450,113 (8%) | 1% | 2.7 | 193,339 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.54 per share. | 04 May 2017 | 9,695 | 440,418 (7%) | 0% | 2.5 | 24,625 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.97 per share. | 04 May 2017 | 2,278 | 101,171 (1%) | 0% | 3.0 | 6,766 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.70 per share. | 04 May 2017 | 13,893 | 87,278 (1%) | 0% | 2.7 | 37,511 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | 04 May 2017 | 250,000 | 583,334 (10%) | 4% | 0.8 | 200,000 | Common Stock | |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.01 per share. | 04 May 2017 | 49,875 | 533,459 (9%) | 0% | 4.0 | 199,999 | Common Stock |
| Randal J. Kirk | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.97 per share. | 04 May 2017 | 11,739 | 521,720 (9%) | 0% | 3.0 | 34,865 | Common Stock |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2017 | 50,000 | 50,000 | - | - | Option (Right to Buy) | |
| Karen Krumeich | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2017 | 20,000 | 20,000 | - | - | Option (Right to Buy) | |
| Richard Straube | SVP and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2017 | 20,000 | 20,000 | - | - | Option (Right to Buy) | |
| Oreola Donini | SVP and CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2017 | 20,000 | 20,000 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 15,804 | 25,095 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 19,755 | 19,755 | - | - | Common Stock Warrant | |
| Robert J. Rubin | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 3,165 | 4,385 | - | - | Common Stock | |
| Robert J. Rubin | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 3,956 | 3,956 | - | - | Common Stock Warrant | |
| Marco Brughera | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 2,000 | 2,750 | - | - | Common Stock | |
| Marco Brughera | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Dec 2016 | 2,500 | 2,500 | - | - | Common Stock Warrant | |
| Karen Krumeich | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 100,000 | 100,000 | - | - | Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 40,541 | 40,541 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 40,541 | 40,541 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 40,541 | 40,541 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 40,541 | 40,541 | - | - | Stock Option (Right to Buy) | |
| Marco Brughera | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 40,541 | 40,541 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2015 | 140,000 | 140,000 | - | - | Option (Right to Buy) | |
| Joseph M. Warusz | VP of Finance/Acting CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2015 | 55,000 | 55,000 | - | - | Option (Right to Buy) | |
| Richard Straube | Senior VP and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2015 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Oreola Donini | SVP and CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2015 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 23 Dec 2015 | 2,500 | 69,166 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2015 | 10,000 | 85,761 | - | - | Common Stock | |
| Gregg Anthony Lapointe | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2015 | 25,000 | 73,781 | - | - | Common Stock | |
| Gregg Anthony Lapointe | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2015 | 25,000 | 0 | - | - | Common Stock Warrant | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2015 | 7,143 | 0 | - | - | Common Stock Warrant | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2015 | 7,143 | 82,904 | - | - | Common Stock | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2015 | 19,868 | 19,868 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2015 | 19,868 | 19,868 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2015 | 19,868 | 19,868 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2015 | 19,868 | 19,868 | - | - | Stock Option (Right to Buy) | |
| Marco Brughera | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2015 | 19,868 | 19,868 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2015 | 17,857 | 0 | - | - | Common Stock Warrant | |
| Jerome Bernard Zeldis | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2015 | 17,857 | 66,666 | - | - | Common Stock | |
| Keith L. Brownlie | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2015 | 14,286 | 0 | - | - | Common Stock Warrant | |
| Keith L. Brownlie | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2015 | 14,286 | 50,000 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2014 | 4,959 | 4,959 | - | - | Common Stock Warrant | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2014 | 8,265 | 75,761 | - | - | Common Stock | |
| Joseph M. Warusz | VP of Finance/Acting CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2014 | 8,265 | 12,955 | - | - | Common Stock | |
| Joseph M. Warusz | VP of Finance/Acting CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2014 | 4,959 | 4,959 | - | - | Common Stock Warrant | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 100,000 | 100,000 | - | - | Option (Right to Buy) | |
| Joseph M. Warusz | VP of Finance/Acting CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 45,000 | 45,000 | - | - | Option (Right to Buy) | |
| Richard Straube | Sr VP & Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Marco Brughera | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2014 | 7,500 | 7,500 | - | - | Stock Option (Right to Buy) | |
| Marco Brughera | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2014 | 7,500 | 7,500 | - | - | Common Stock | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 13,669 | 13,669 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 13,669 | 13,669 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 13,669 | 13,669 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 13,669 | 13,669 | - | - | Stock Option (Right to Buy) | |
| Marco Brughera | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 13,669 | 13,669 | - | - | Stock Option (Right to Buy) | |
| Joseph M. Warusz | VP of Admin, Controller / PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2014 | 4,690 | 4,690 | - | - | Common Stock | |
| Joseph M. Warusz | VP of Admin, Controller / PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2014 | 4,690 | 25,310 | - | - | Option (Right to Buy) | |
| Keith L. Brownlie | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2014 | 16,667 | 8,333 | - | - | Option (Right to Buy) | |
| Keith L. Brownlie | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2014 | 16,667 | 35,714 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2014 | 7,815 | 112,185 | - | - | Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2014 | 7,815 | 67,496 | - | - | Common Stock | |
| Richard Straube | Senior VP & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2014 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2013 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Robert N. Brey | Chief Scientific Off., Sr. VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2013 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Joseph M. Warusz | VP of Finance and Acting CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2013 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2013 | 13,275 | 13,275 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2013 | 13,275 | 13,275 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2013 | 13,275 | 13,275 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2013 | 13,275 | 13,275 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2013 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Robert N. Brey | Chief Scientific Offr & Sr. VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2013 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Joseph M. Warusz | VP of Finance & Acting CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2013 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Kevin Horgan | Chief Medical Officer & Sr. VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2013 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 7,143 | 7,142 | - | - | Common Stock Warrants | |
| Christopher J. Schaber | Director, Chairman, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 9,523 | 59,681 | - | - | Common Stock | |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 23,809 | 48,809 | - | - | Common Stock | |
| Jerome Bernard Zeldis | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 17,857 | 17,857 | - | - | Common Stock Warrants | |
| Keith L. Brownlie | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 14,286 | 14,285 | - | - | Common Stock Warrants | |
| Keith L. Brownlie | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Jun 2013 | 19,047 | 19,047 | - | - | Common Stock | |
| Jerome Bernard Zeldis | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2013 | 25,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2013 | 25,000 | 25,000 | - | - | Common Stock | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 20 Dec 2012 | 1 | 0 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 20 Dec 2012 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 20 Dec 2012 | 1 | 0 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 20 Dec 2012 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 20 Dec 2012 | 1 | 0 | - | - | Common Stock Warrant (warrant to buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2012 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2012 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2012 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2012 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 10 Apr 2012 | 9,900 | 50,157 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2012 | 333,333 | 805,150 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chairman CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2011 | 2,400,000 | 2,400,000 | - | - | Stock Option (Right to Buy) | |
| Robert N. Brey | Sr VP & Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2011 | 700,000 | 700,000 | - | - | Stock Option (Right to Buy) | |
| Evan Myrianthopoulos | Director, Sr VP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2011 | 1,200,000 | 1,200,000 | - | - | Stock Option (Right to Buy) | |
| Joseph M. Warusz | Other | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2011 | 600,000 | 600,000 | - | - | Stock Option (Right to Buy) | |
| Kevin Horgan | Sr VP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2011 | 1,200,000 | 1,200,000 | - | - | Stock Option (Right to Buy) | |
| Tamar D. Howson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 191,722 | 191,722 | - | - | Stock Option (Right to Buy) | |
| Virgil D. Thompson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 191,722 | 191,722 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 191,722 | 191,722 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 191,722 | 191,722 | - | - | Stock Option (Right to Buy) | |
| Jerome Bernard Zeldis | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Keith L. Brownlie | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2011 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Joseph M. Warusz | Other | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2011 | 800,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Kevin Horgan | Senior VP; Chief Med Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2011 | 1,250,000 | 1,250,000 | - | - | Stock Option (Right to Buy) | |
| Tamar D. Howson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Christopher J. Schaber | Director, Chairman CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 2,200,000 | 2,200,000 | - | - | Stock Option (Right to Buy) | |
| Robert N. Brey | Chief Science Officer & Sr VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 850,000 | 850,000 | - | - | Stock Option (Right to Buy) | |
| Virgil D. Thompson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Evan Myrianthopoulos | Director, CFO and Senior Vice Presient | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 1,050,000 | 1,050,000 | - | - | Stock Option (Right to Buy) | |
| Christopher P. Schnittker | VP-Admin., Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 700,000 | 700,000 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 187,500 | 187,500 | - | - | Stock Option (Right to Buy) | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Brian L. Hamilton | Chief Medical Officer & Sr VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Sep 2010 | 800,000 | 800,000 | - | - | Stock Option (Right to Buy) | |
| Gregg Anthony Lapointe | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2010 | 975,610 | 975,610 | - | - | Common Stock | |
| Robert J. Rubin | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2010 | 243,902 | 243,902 | - | - | Common Stock | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Jun 2010 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Jun 2010 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Paolo Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2010 | 8,608,580 | 54,227,816 | - | - | Common Stock | |
| Paolo Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2010 | 2,926,829 | 3,282,929 | - | - | Common Stock | |
| Claudio Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Jun 2010 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Claudio Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2010 | 8,608,580 | 54,227,816 | - | - | Common Stock | |
| Robert J. Rubin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Oct 2009 | 300,000 | 300,000 | - | - | Stock Options (right to buy) | |
| Christopher J. Schaber | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 Sep 2009 | 79,051 | 471,817 | - | - | Common Stock | |
| Paolo Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 24 Sep 2009 | 3,952,569 | 45,619,236 | - | - | Common Stock | |
| Paolo Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 24 Sep 2009 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Claudio Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 24 Sep 2009 | 3,952,569 | 45,619,236 | - | - | Common Stock | |
| Claudio Cavazza | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 24 Sep 2009 | 1 | 1 | - | - | Common Stock Warrant (warrant to buy) | |
| Christopher P. Schnittker | VP ADMIN CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2009 | 750,000 | 750,000 | - | - | Stock Option (Right to Buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2009 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2009 | 37,500 | 37,500 | - | - | Stock Options (right to buy) | |
| Cyrille F. Buhrman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2009 | 250,000 | 250,000 | - | - | Stock Options (right to buy) | |
| Robert N. Brey | Chief Scientific Officer/SrVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2009 | 9,000 | 9,000 | - | - | Stock Options (Right to Buy) | |
| Robert N. Brey | Chief Scientific Officer/SrVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2009 | 600,000 | 600,000 | - | - | Stock Options (Right to Buy) | |
| Robert N. Brey | Chief Scientific Officer/SrVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2009 | 200,000 | 200,000 | - | - | Stock Options (Right to Buy) | |
| Robert N. Brey | Chief Scientific Officer/SrVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2009 | 800,000 | 800,000 | - | - | Stock Options (Right to Buy) | |
| Brian L. Hamilton | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2009 | 1,000,000 | 1,000,000 | - | - | Stock Options (right to buy) | |
| Gregg Anthony Lapointe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2009 | 300,000 | 300,000 | - | - | Stock Options (right to buy) | |
| Paolo Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Feb 2009 | 25,000,000 | 41,666,667 | - | - | Common Stock | |
| Claudio Cavazza | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Feb 2009 | 25,000,000 | 41,666,667 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2008 | 2,800,000 | 2,800,000 | - | - | Stock Option (Right to Buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2008 | 1,200,000 | 1,200,000 | - | - | Stock Options (Right to Buy) | |
| James Clavijo | Controller/Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2008 | 600,000 | 600,000 | - | - | Stock Option (Right to Buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2007 | 75,000 | 75,000 | - | - | Stock Option (right to buy) | |
| Cyrille F. Buhrman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2007 | 75,000 | 75,000 | - | - | Stock Options (right to buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Aug 2007 | 70,000 | 224,780 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 Aug 2007 | 100,000 | 392,766 | - | - | Common Stock | |
| James Clavijo | Controller/Treasurer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 Aug 2007 | 35,000 | 88,191 | - | - | Common Stock | |
| Christopher J. Schaber | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2007 | 500,000 | 500,000 | - | - | Stock Options (right ot buy) | |
| Christopher J. Schaber | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2007 | 900,000 | 900,000 | - | - | Stock Options (Right to Buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2007 | 550,000 | 550,000 | - | - | Stock Options (Right to Buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2007 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| James Clavijo | Controller/Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2007 | 300,000 | 300,000 | - | - | Stock Options (Right to Buy) | |
| Cyrille F. Buhrman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2007 | 150,000 | 150,000 | - | - | Stock Options (right to buy) | |
| Christopher J. Schaber | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Feb 2007 | 212,766 | 292,766 | - | - | Common Stock | |
| Steve H. Kanzer | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Feb 2007 | 212,766 | 1,282,203 | - | - | Common Stock | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Feb 2007 | 53,191 | 154,817 | - | - | Common Stock | |
| James Clavijo | Controller/Treasurer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Feb 2007 | 53,191 | 53,191 | - | - | Common Stock | |
| Steve H. Kanzer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2007 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2006 | 400,000 | 400,000 | - | - | Stock Options (right to buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2006 | 90,220 | 90,220 | - | - | Common Stock | |
| James Clavijo | Controller/Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2006 | 200,000 | 200,000 | - | - | Stock Options (right to buy) | |
| Michael T. Sember | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2006 | 180,440 | 180,440 | - | - | Common Stock | |
| Michael T. Sember | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2006 | 2,000,000 | 2,000,000 | - | - | Stock Options (right to buy) | |
| Michael T. Sember | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2006 | 180,440 | 180,440 | - | - | Stock Warrants (right to buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2006 | 90,220 | 90,220 | - | - | Common Stock | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2006 | 90,220 | 90,220 | - | - | Stock Warrants (right to buy) | |
| Steve H. Kanzer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2006 | 250,000 | 1,069,437 | - | - | Common Stock | |
| Steve H. Kanzer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2006 | 250,000 | 0 | - | - | Stock Options (right to buy) | |
| Steve H. Kanzer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2006 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2006 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Alexander P. Haig | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2006 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| T. Jerome Madison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2006 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| James Clavijo | Controller/Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2005 | 150,000 | 150,000 | - | - | Stock Options (right to buy) | |
| James Clavijo | Controller/Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2005 | 100,000 | 100,000 | - | - | Stock Options (right to buy) | |
| Evan Myrianthopoulos | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2004 | 500,000 | 500,000 | - | - | Stock Options (right to buy) | |
| Peter Salomon | Other | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Arthur Asher Kornbluth | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Lawrence Jay Kessel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Nov 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Evan Myrianthopoulos | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Nov 2004 | 150,000 | 150,000 | - | - | Stock Options (right to buy) | |
| Alexander P. Haig | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Nov 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Lawrence Jay Kessel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Lawrence Jay Kessel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Peter Salomon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Peter Salomon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 10,000 | 415,000 | - | - | Common Stock | |
| Peter Salomon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Steve H. Kanzer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options | |
| Arthur Asher Kornbluth | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Evan Myrianthopoulos | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| James S. Kuo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Alexander P. Haig | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2004 | 50,000 | 50,000 | - | - | Stock Options (right to buy) | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 1,141,622 | 168,692 | - | - | Warrant | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 367,340 | 168,692 | - | - | Warrant | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 292,411 | 168,692 | - | - | Warrant | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 66,931 | 168,692 | - | - | Warrant | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 82,469 | 168,692 | - | - | Warrant | |
| Lindsay A. Rosenwald | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 12 Feb 2004 | 886,399 | 3,230,922 | - | - | Equity |